
Hemodynamic Software, Project nGene.org®
Hyunsuk Frank Roh, MD: Echocardiographer & IRB Chair
#1/2 The Mythical Man-Month: Prologue of my Life Ahead (written in 2013)
Throughout an entire undergraduate semester in 2006, Professor Elliot Soloway repeatedly read aloud selections from the book, The Mythical Man-Month by Fred Brooks. The particularly memorable quote from the book about being a software architect read as follows: "The man-month as a unit of measuring the size of a job is a dangerous and deceptive myth." In other words, if the software architect decides to increase the manpower in order to decrease the month required for the software development, it is likely to, rather, deteriorate the project by increasing the intercommunication complexity. Fortunately, this principle, highlighted by Soloway, resonated with me based on my past experiences.
Professor Robert Denver provided me with an excellent opportunity to learn basic molecular biology lab techniques. He assigned me the task of sequencing a gene from Xenopus tropicalis using Vector NTI software. This introduction to bioinformatics was pivotal, propelling me towards further interdisciplinary research in computer science and biology. Later, I serendipitously attended "Computational Biology Short Courses" in August 2004, where I was introduced to a broad range of computational biology topics by various instructors, including Professor David States, the developer of BLASTX. The BLAST algorithm captivated me and has profoundly influenced me ever since, as demonstrated by my BLASTed logo.
nGene, along with "enGine" and "&Gene," shares a similar pronunciation, and these terms can be visually aligned and color-coded, reminiscent of how DNA or protein sequences are presented in Vector NTI software.
Professor Jignesh Patel gracefully allowed me to attend his weekly Bioinformatics seminar and assigned me a programming project to evaluate phylogenetic tree-generating algorithms. There, I realized that, in an interdisciplinary field, there could not be enough emphasis on communication between Apple and Orange in order to be on the same page; in this sense, being a chimera myself, trained in both fields, I can help (1) by not doubling the number of "men" required and (2) by reducing the "intercommunication complexity" on a manageable level. During the past seven years, there were many tears and changes in my life... And yet, I can still feel my heart pumping with joyful anticipation about working on the interdisciplinary topic because of my belief that someday I will hopefully make an important contribution to this interdisciplinary field that had once seized me with the BLASTed heart.
- Written during my 2013 trip to British Columbia/California
